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Music video by Rihanna performing Take A Bow. YouTube view counts pre-VEVO: 66288884. (C) 2008 The Island Def Jam Music Group.
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Jimmy Kimmel Live - Celebrities Read Mean Tweets #2 Jimmy Kimmel Live's YouTube channel features clips and recaps of every episode from the late night TV sho...
Watch Season 1 of Mortal Kombat Legacy here: http://www.youtube.com/channel/SWVkIoQKmEa4I The Mortal Kombat Legacy continues in Season 2 as Liu Kang, Kung La...
So i was pretty hesitant to make this video... but after all of your request, here is my Draw My Life video! Check out my 2nd Channel for more vlogs: http://...
Music video by Adele performing Rolling In The Deep. (C) 2010 XL Recordings Ltd. #VEVOCertified on July 25, 2011. http://www.vevo.com/certified http://www.yo...
Music video by P!nk performing Try (The Truth About Love - Live From Los Angeles). (C) 2012 RCA Records, a division of Sony Music Entertainment.
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Jimmy Kimmel Live - Celebrities Read Mean Tweets #3 Jimmy Kimmel Live's YouTube channel features clips and recaps of every episode from the late night TV sho...
Don't be these people. Mapoti See Bloopers and Behind-The-Scenes Here!: http://youtu.be/dfpo7uXwJnM Huge thank you and shout out to Dtrix: http://www.youtube...
|Jmol-3D images||Image 1|
|Molar mass||58.08 g mol−1|
|Odor||Pungent, irritating, floral|
|Density||0.791 g cm−3|
-95--93 °C, 178-180 K, -139--136 °F
56-57 °C, 329-330 K, 133-134 °F
|Vapor pressure||24.46–24.60 kPa (at 20 °C)|
|Refractive index (nD)||1.35900|
|Trigonal planar at C2|
|Molecular shape||Dihedral at C2|
|Dipole moment||2.91 D|
|Std enthalpy of
|-250.03-(−248.77) kJ mol−1|
|Std enthalpy of
|-1.772 MJ mol−1|
|200.4 J K−1 mol−1|
|Specific heat capacity, C||125.45 J K−1 mol−1|
|GHS signal word||DANGER|
|GHS hazard statements||H225, H319, H336|
|GHS precautionary statements||P210, P261, P305+351+338|
|EU classification||F Xi|
|R-phrases||R11, R36, R66, R67|
|S-phrases||(S2), S9, S16, S26|
|Flash point||−17 °C|
|Threshold Limit Value||1185 mg/m3 (TWA), 2375 mg/m3 (STEL)|
|LD50||3000 mg/kg (oral, mouse), 20000 mg/kg (dermal, rabbit), LC50 = 19000 mg/m3 (inhalation)|
|Supplementary data page|
|n, εr, etc.|
Solid, liquid, gas
|Spectral data||UV, IR, NMR, MS|
| (what is: / ?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Acetone is miscible with water and serves as an important solvent in its own right, typically for cleaning purposes in the laboratory. About 6.7 million tonnes were produced worldwide in 2010, mainly for use as a solvent and production of methyl methacrylate and bisphenol A. It is a common building block in organic chemistry. Familiar household uses of acetone are as the active ingredient in nail polish remover and as paint thinner.
Acetone is produced and disposed of in the human body through normal metabolic processes. It is normally present in blood and urine. People with diabetes produce it in larger amounts. Reproductive toxicity tests show that it has low potential to cause reproductive problems. Pregnant women nursing mothers and children have higher levels of acetone. Ketogenic diets that increase acetone in the body are used to reduce epileptic attacks in infants and children who suffer from recalcitrant refractory epilepsy.
|This section requires expansion. (December 2011)|
Small amounts of acetone are produced in the body by the decarboxylation of ketone bodies. Certain dietary patterns, including prolonged fasting and high-fat low-carbohydrate dieting, can produce ketosis, in which acetone is formed in body tissue, and certain health conditions, such as alcoholism and diabetes, can produce ketoacidosis, uncontrollable ketosis that leads to a sharp, and potentially fatal, increase in the acidity of the blood. Since it is a byproduct of fermentation, acetone is a byproduct of the distillery industry.
In 2010, the worldwide production capacity for acetone was estimated at 6.7 million tonnes per year. With 1.56 million tonnes per year, the United States had the highest production capacity, followed by Taiwan and mainland China. The largest producer of acetone is INEOS Phenol, owning 17% of the world's capacity, with also significant capacity (7–8%) by Mitsui, Sunoco and Shell in 2010. INEOS Phenol also owns the world's largest production site (420,000 tonnes/annum) in Beveren (Belgium). Spot price of acetone in summer 2011 was 1100–1250 USD/tonne in the United States.
Current method 
Acetone is produced directly or indirectly from propylene. Approximately 83% of acetone is produced via the cumene process, as a result, acetone production is tied to phenol production. In the cumene process, benzene is alkylated with propylene to produce cumene, which is oxidized by air to produce phenol and acetone:
Older methods 
- Ca(CH3COO)2 → CaO(s) + CO2(g) + (CH3)2CO(v)
Before that, during World War I acetone was produced using acetone-butanol-ethanol fermentation with Clostridium acetobutylicum bacteria, which was developed by Chaim Weizmann (later the first president of Israel) in order to help the British war effort in the preparation of Cordite. This acetone-butanol-ethanol fermentation was eventually abandoned when newer methods with better yields were found.
Acetone is a good solvent for many plastics and some synthetic fibers. It is used for thinning polyester resin, cleaning tools used with it, and dissolving two-part epoxies and superglue before they harden. It is used as one of the volatile components of some paints and varnishes. As a heavy-duty degreaser, it is useful in the preparation of metal prior to painting. It is also useful for high reliability soldering applications to remove rosin flux after soldering is complete; this helps to prevent the Rusty bolt effect.
Although itself flammable, acetone is used extensively as a solvent for the safe transporting and storing of acetylene, which cannot be safely pressurized as a pure compound. Vessels containing a porous material are first filled with acetone followed by acetylene, which dissolves into the acetone. One liter of acetone can dissolve around 250 liters of acetylene.
Chemical intermediate 
- (CH3)2CO + HCN → (CH3)2C(OH)CN
- (CH3)2C(OH)CN + CH3OH → CH2=(CH3)CCO2CH3 + NH3
The third major use of acetone (about 20%) is synthesizing bisphenol A. Bisphenol A is a component of many polymers such as polycarbonates, polyurethanes, and epoxy resins. The synthesis involves the condensation of acetone with phenol:
- (CH3)2CO + 2 C6H5OH → (CH3)2C(C6H4OH)2 + H2O
Many millions of kilograms of acetone are consumed in the production of the solvents methyl isobutyl alcohol and methyl isobutyl ketone. These products arise via an initial aldol condensation to give diacetone alcohol.
- 2 (CH3)2CO → (CH3)2C(OH)CH2C(O)CH3
In the laboratory, acetone is used as a polar, aprotic solvent in a variety of organic reactions, such as SN2 reactions. The use of acetone solvent is critical for the Jones oxidation. It does not form an azeotrope with water (see azeotrope (data)). It is a common solvent for rinsing laboratory glassware because of its low cost and volatility. Despite its common use as a supposed drying agent, it is not effective except by bulk displacement and dilution. Acetone can be cooled with dry ice to −78 °C without freezing; acetone/dry ice baths are commonly used to conduct reactions at low temperatures. Acetone is fluorescent under ultraviolet light, and its vapor may be used as a fluorescent tracer in fluid flow experiments.
Medical and cosmetic uses 
Acetone is used in a variety of general medical and cosmetic applications and is also listed as a component in food additives and food packaging. Dermatologists use acetone with alcohol for acne treatments to peel dry skin.
Acetone is commonly used in chemical peeling. Common agents used today for chemical peels are salicylic acid, glycolic acid, 30% salicylic acid in ethanol, and trichloroacetic acid (TCA). Prior to chemexfoliation, the skin is cleaned and excess fat removed in a process called defatting. Acetone, Septisol, or a combination of these agents is commonly used in this process.
Domestic and other niche uses 
Acetone is often the primary component in cleaning agents such as nail polish remover. Acetone is a component of superglue remover and easily removes residues from glass and porcelain. Make-up artists use acetone to remove skin adhesive from the netting of wigs and moustaches by immersing the item in an acetone bath, then removing the softened glue residue with a stiff brush.
This chemical is also used as an artistic agent; when rubbed on the back of a laser print or photocopy placed face-down on another surface and burnished firmly, the toner of the image transfers to the destination surface.
Acetone can also be used in combination with automatic transmission fluid to create an effective penetrating oil. Brake fluid is sometimes used in place of ATF. These mixtures (usually 1:1) can be useful in loosening rusted or stuck bolts.
The most hazardous property of acetone is its extreme flammability. At temperatures greater than acetone's flash point of −20 °C (−4 °F), air mixtures of between 2.5% and 12.8% acetone, by volume, may explode or cause a flash fire. Vapors can flow along surfaces to distant ignition sources and flash back. Static discharge may also ignite acetone vapors. Acetone has, however very high ignition initiation energy point, so accidental ignition is rare. Even pouring or spraying acetone over red-glowing coal will not ignite it, due to the high concentration of vapour and the cooling effect of evaporation of the liquid. It auto-ignites at 465 °C (869 °F). Autoignition temperature is also dependent upon the exposure time, thus at some tests it is quoted as 525°C. Also, industrial acetone is likely to contain small amount of water which also inhibits ignition.
Acetone peroxide 
When oxidized, acetone forms acetone peroxide as a byproduct, which is a highly unstable compound. It may be formed accidentally, e.g. when waste hydrogen peroxide is poured into waste solvent containing acetone. Due to its instability, it is rarely used, despite its easy chemical synthesis.
Health information 
Acetone has been studied extensively and is generally recognized to have low acute and chronic toxicity if ingested and/or inhaled. Inhalation of high concentrations (around 9200 ppm) in the air caused irritation of the throat in humans in as little as 5 minutes. Inhalation of concentrations of 1000 ppm caused irritation of the eyes and of the throat in less than 1 hour; however, the inhalation of 500 ppm of acetone in the air caused no symptoms of irritation in humans even after 2 hours of exposure. Acetone is not currently regarded as a carcinogen, a mutagenic chemical or a concern for chronic neurotoxicity effects.
Acetone can be found as an ingredient in a variety of consumer products ranging from cosmetics to processed and unprocessed foods. Acetone has been rated as a GRAS (Generally Recognized as Safe) substance when present in beverages, baked foods, desserts, and preserves at concentrations ranging from 5 to 8 mg/L. Additionally, a joint U.S-European study found that acetone's "health hazards are slight."
Acetone is believed to exhibit only slight toxicity in normal use, and there is no strong evidence of chronic health effects if basic precautions are followed.
At very high vapor concentrations, acetone is irritating and, like many other solvents, may depress the central nervous system. It is also a severe irritant on contact with eyes, and a potential pulmonary aspiration risk. In one documented case, ingestion of a substantial amount of acetone led to systemic toxicity, although the patient eventually fully recovered. Some sources estimate LD50 for human ingestion at 1.159 g/kg; LD50 inhalation by mice is given as 44 g/m3, over 4 hours.
Acetone has been shown to have anticonvulsant effects in animal models of epilepsy, in the absence of toxicity, when administered in millimolar concentrations. It has been hypothesized that the high-fat low-carbohydrate ketogenic diet used clinically to control drug-resistant epilepsy in children works by elevating acetone in the brain.
- EPA EPCRA Delisting (1995). EPA removed acetone from the list of "toxic chemicals" maintained under Section 313 of the Emergency Planning and Community Right to Know Act (EPCRA). In making that decision, EPA conducted an extensive review of the available toxicity data on acetone and found that acetone "exhibits acute toxicity only at levels that greatly exceed releases and resultant exposures", and further that acetone "exhibits low toxicity in chronic studies".
- Genotoxicity. Acetone has been tested in more than two dozen in vitro and in vivo assays. These studies indicate that acetone is not genotoxic.
- Carcinogenicity. EPA in 1995 concluded, "There is currently no evidence to suggest a concern for carcinogenicity". (EPCRA Review, described in Section 3.3). NTP scientists have recommended against chronic toxicity/carcinogenicity testing of acetone because "the prechronic studies only demonstrated a very mild toxic response at very high doses in rodents".
- Neurotoxicity and Developmental Neurotoxicity. The neurotoxic potential of both acetone and isopropanol, the metabolic precursor of acetone, have been extensively studied. These studies demonstrate that although exposure to high doses of acetone may cause transient central nervous system effects, acetone is not a neurotoxicant. A guideline developmental neurotoxicity study has been conducted with isopropanol, and no developmental neurotoxic effects were identified, even at the highest dose tested. (SIAR, pp. 1, 25, 31).
- Environmental. When the EPA exempted acetone from regulation as a volatile organic compound (VOC) in 1995, EPA stated that this exemption would "contribute to the achievement of several important environmental goals and would support EPA's pollution prevention efforts". 60 Fed. Reg. 31,634 (June 16, 1995). 60 Fed. Reg. 31,634 (June 16, 1995). EPA noted that acetone could be used as a substitute for several compounds that are listed as hazardous air pollutants (HAP) under section 112 of the Clean Air Act.
Environmental effects 
Acetone evaporates rapidly, even from water and soil. Once in the atmosphere, it has a 22-day half-life and is degraded by UV light via photolysis (primarily into methane and ethane). Acetone dissipates slowly in soil, animals, or waterways since it is sometimes consumed by microorganisms, but it is a significant groundwater contaminant due to its high solubility in water. The LD50 of acetone for fish is 8.3 g/L of water (or about 1%) over 96 hours, and its environmental half-life is about 1 to 10 days. Acetone may pose a significant risk of oxygen depletion in aquatic systems due to the microbial consumption.
- Merck Index, 11th Edition, 58
- "Acetone – PubChem Public Chemical Database". The PubChem Project. USA: National Center for Biotechnology Information.
- "Acetone". NIST Chemistry WebBook. USA: National Institute of Standards and Technology.
- Klamt, Andreas (2005). COSMO-RS: From Quantum Chemistry to Fluid Phase Thermodynamics and Drug Design. Elsevier. pp. 92–94. ISBN 978-0-444-51994-8.
- Ash, Michael; Ash, Irene (2004). Handbook of preservatives. Synapse Information Resources, Inc. p. 369. ISBN 1-890595-66-7.
- Myers, Richard L. (2007). The 100 Most Important Chemical Compounds: A Reference Guide. Greenwood. pp. 4–6. ISBN 978-0-313-08057-9.
- Acetone, World Petrochemicals report, January 2010
- Stylianos Sifniades, Alan B. Levy, "Acetone" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim, 2005.
- Camara Greiner, EO and Funada, C (June 2010). "CEH Marketing Research Report: ACETONE". Chemical Economics Handbook. SRI consulting. Retrieved March 2011.
- "Acetone Uses and Market Data". ICIS.com. October 2010. Retrieved 2011-03-21.
- Acetone (US Gulf) Price Report – Chemical pricing information. ICIS Pricing. Retrieved on 2012-11-26.
- Wittcoff, M.M. Green ; H.A. (2003). Organic chemistry principles and industrial practice (1. ed., 1. reprint. ed.). Weinheim: Wiley-VCH. p. 4. ISBN 3-527-30289-1.
- Weiner, Myra L.; Lois A. Kotkoskie (1999). Excipient Toxicity and Safety. p. 32. ISBN 978-0-8247-8210-8.
- Inactive Ingredient Search for Approved Drug Products, FDA/Center for Drug Evaluation and Research
- Mine Safety and Health Administration (MSHA) – Safety Hazard Information – Special Hazards of Acetylene. Msha.gov. Retrieved on 2012-11-26.
- History – Acetylene dissolved in acetone. Aga.com. Retrieved on 2012-11-26.
- What is an Azeotrope?. Solvent—recycling.com. Retrieved on 2012-11-26.
- A. Lozano, B. Yip and R. K. Hanson (1992). "Acetone: a tracer for concentration measurements in gaseous flows by planar laser-induced fluorescence". Exp. Fluids 13 (6): 369–376. doi:10.1007/BF00223244.
- Acetone MSDS. Hazard.com (1998-04-21). Retrieved on 2012-11-26.
- Basic Information on Acetone. Ccohs.ca (1999-02-19). Retrieved on 2012-11-26.
- Canadian Centre for Occupational Health and Safety. "Health Effects of Acetone". Archived from the original on 17 October 2008. Retrieved 2008-10-21.
- Safety (MSDS) data for propanone. Msds.chem.ox.ac.uk. Retrieved on 2012-11-26.
- Likhodii SS, Serbanescu I, Cortez MA, Murphy P, Snead OC 3rd, Burnham WM (2003). "Anticonvulsant properties of acetone, a brain ketone elevated by the ketogenic diet". Ann Neurol. 54 (2): 219–226. doi:10.1002/ana.10634. PMID 12891674.
- Darwent, B. deB.; Allard, M. J.; Hartman, M. F.; Lange, L. J. (1960). "The Photolysis of Acetone". Journal of Physical Chemistry 64 (12): 1847. doi:10.1021/j100841a010.
- Acetone, Agency for Toxic Substances and Disease Registry ToxFAQs, 1995
- Safety Data Sheet Acetone. (PDF) . Retrieved on 2012-11-26.
- International Chemical Safety Card 0087
- National Pollutant Inventory: Acetone
- NIOSH Pocket Guide to Chemical Hazards
- Hazardous substances databank entry at the national library of medicine
- SIDS Initial Assessment Report for Acetone from the Organisation for Economic Co-operation and Development (OECD)
- Calculation of vapor pressure, liquid density, dynamic liquid viscosity, surface tension of acetone