Bone morphogenetic protein receptor, type IA
PDB rendering based on 1es7.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1ES7, 1REW, 2GOO, 2H62, 2H64, 2K3G, 2QJ9, 2QJA, 2QJB, 3NH7, 3QB4
Identifiers
Symbols	BMPR1A; 10q23del; ACVRLK3; ALK3; CD292; SKR5
External IDs	OMIM: 601299 MGI: 1338938 HomoloGene: 20911 ChEMBL: 5275 GeneCards: BMPR1A Gene
EC number	2.7.11.30
Gene Ontology Molecular function • sequence-specific DNA binding RNA polymerase II transcription factor activity • protein serine/threonine kinase activity • transmembrane receptor protein serine/threonine kinase activity • transforming growth factor beta-activated receptor activity • protein binding • ATP binding • protein homodimerization activity • SMAD binding • metal ion binding Cellular component • plasma membrane • caveola • integral to membrane • dendrite • neuronal cell body Biological process • in utero embryonic development • mesoderm formation • somitogenesis • Mullerian duct regression • positive regulation of mesenchymal cell proliferation • endocardial cushion formation • protein phosphorylation • immune response • transforming growth factor beta receptor signaling pathway • ectoderm development • dorsal/ventral axis specification • positive regulation of pathway-restricted SMAD protein phosphorylation • neural crest cell development • stem cell maintenance • pituitary gland development • neural plate mediolateral regionalization • lung development • positive regulation of bone mineralization • BMP signaling pathway • hindlimb morphogenesis • odontogenesis of dentin-containing tooth • embryonic digit morphogenesis • positive regulation of osteoblast differentiation • positive regulation of transcription, DNA-dependent • paraxial mesoderm structural organization • lateral mesoderm development • regulation of lateral mesodermal cell fate specification • mesendoderm development • embryonic organ development • developmental growth • positive regulation of epithelial cell proliferation • negative regulation of neurogenesis • cartilage development • palate development • positive regulation of SMAD protein import into nucleus • heart formation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	657	12166
Ensembl	ENSG00000107779	ENSMUSG00000021796
UniProt	P36894	P36895
RefSeq (mRNA)	NM_004329	NM_009758
RefSeq (protein)	NP_004320	NP_033888
Location (UCSC)	Chr 10: 88.52 – 88.68 Mb	Chr 14: 34.41 – 34.5 Mb
PubMed search	[1]	[2]
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The bone morphogenetic protein receptor, type IA also known as BMPR1A is a protein which in humans is encoded by the BMPR1A gene. BMPR1A has also been designated as CD292 (cluster of differentiation 292).^[1]

Function [edit]

The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.^[1]

BMP's repress WNT signaling to maintain stable stem cell populations. BMPR1A null mice died at embyonic day 8.0 without mesoderm specification, demonstrating its vital role in gastrulation.^[2] It has been demonstrated in experiments using dominant negative BMPR1A chick embryos that BMPR1A plays a role in apoptosis and adipocyte development.^[2] Using constitutively active forms of BMR1A it has been shown that it plays a role in cell differentiation.^[2] Signals tranduced by the BMPR1A receptor are not essential for osteoblast formation or proliferation; however, BMPR1A is necessary for the extracellular matrix depostition by osteoblasts.^[2] In the chick embryo, BMPR1A receptors are found in low levels in limb bud mesenchyme, a differing location to BMPR1B, supporting the differing roles they play in osteogenesis.^[3]

Ligands [edit]

• Agonists: BMP2, BMP4, BMP6, BMP7, GDF6
• Antagonists: Noggin, Chordin

Diseases [edit]

BMPR1A, SMAD4 and PTEN are responsible for Juvenile polyposis syndrome, juvenile intestinal polyposis and Cowden's disease.

Interactions [edit]

BMPR1A has been shown to interact with SF3B4,^[4] ZMYND11^[5] and Bone morphogenetic protein 2.^[6][7][8][9]

References [edit]

Further reading [edit]

v t e PDB gallery 1es7: COMPLEX BETWEEN BMP-2 AND TWO BMP RECEPTOR IA ECTODOMAINS  1rew: Structural refinement of the complex of bone morphogenetic protein 2 and its type IA receptor  2goo: Ternary Complex of BMP-2 bound to BMPR-Ia-ECD and ActRII-ECD  2h62: Crystal structure of a ternary ligand-receptor complex of BMP-2  2h64: Crystal structure of a ternary ligand-receptor complex of BMP-2

External links [edit]

• GeneReviews/NCBI/NIH/UW entry on Juvenile Polyposis Syndrome
• BMPR1A protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)