Research
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DCP2 Images
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Rihanna - Take A BowMusic video by Rihanna performing Take A Bow. YouTube view counts pre-VEVO: 66288884. (C) 2008 The Island Def Jam Music Group.
P!nk - Just Give Me A Reason (Official Lyric Video)The Truth About Love available on iTunes NOW http://smarturl.it/tal Music video by P!nk performing Just Give Me A Reason. (C) 2012 RCA Records, a division of...
Celebrities Read Mean Tweets #2Jimmy Kimmel Live - Celebrities Read Mean Tweets #2 Jimmy Kimmel Live's YouTube channel features clips and recaps of every episode from the late night TV sho...
David Guetta - Just One Last Time ft. Taped Rai"Just One Last Time" feat. Taped Rai. Available to download on iTunes including remixes of : Tiësto, HARD ROCK SOFA & Deniz Koyu http://smarturl.it/DGJustOne...
Jimmy Kimmel Lie Detective #1Jimmy Kimmel Live - Jimmy Kimmel Lie Detective #1 Jimmy Kimmel Live's YouTube channel features clips and recaps of every episode from the late night TV show ...
MACKLEMORE & RYAN LEWIS - CAN'T HOLD US FEAT. RAY DALTON (OFFICIAL MUSIC VIDEO)Macklemore & Ryan Lewis present the official music video for Can't Hold Us feat. Ray Dalton. Can't Hold Us on iTunes: https://itunes.apple.com/us/album/cant-...
Draw My Life- Jenna MarblesThis video accidentally turned out kind of sad, ME SO SOWWY IT NOT POSED TO BE SAD WHO WANTS HUGS AND COOKIES? Also, FYI for anyone attempting this, it takes...
Draw My Life - Ryan HigaSo i was pretty hesitant to make this video... but after all of your request, here is my Draw My Life video! Check out my 2nd Channel for more vlogs: http://...
Key & Peele: Substitute TeacherA substitute teacher from the inner city refuses to be messed with while taking attendance.
Jack Sparrow (feat. Michael Bolton)Buy at iTunes: http://goo.gl/zv4o9. New album on sale now! http://turtleneckandchain.com.
Katy Perry - Wide AwakeOfficial music video for "Wide Awake," the final chapter from 'Teenage Dream: The Complete Confection' on iTunes: http://smarturl.it/katyperry. Written by Ka...
This article is about the gene and encoded protein. For the Disease Control Priorities in Developing Countries Report (2nd edition), see Disease Control Priorities Project.
mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.[1][2][3]
DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM][3]
Interactions [edit]
DCP2 has been shown to interact with DCP1A[4] and UPF1.[2][5]
References [edit]
- ^ Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (Oct 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme pro-caratine". Proc Natl Acad Sci U S A 99 (20): 12663–8. doi:10.1073/pnas.192445599. PMC 130517. PMID 12218187.
- ^ a b Lykke-Andersen J (Nov 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol Cell Biol 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.
- ^ a b "Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)".
- ^ Lykke-Andersen, Jens (Dec. 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Mol. Cell. Biol. (United States) 22 (23): 8114–21. doi:10.1128/MCB.22.23.8114-8121.2002. ISSN 0270-7306. PMC 134073. PMID 12417715.
- ^ Lejeune, Fabrice; Li Xiaojie, Maquat Lynne E (Sep. 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Mol. Cell (United States) 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. ISSN 1097-2765. PMID 14527413.
Further reading [edit]
- Ueno K, Kumagai T, Kijima T, et al. (1998). "Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer.". Hum. Genet. 102 (1): 63–8. doi:10.1007/s004390050655. PMID 9490301.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- van Dijk E, Cougot N, Meyer S, et al. (2004). "Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures.". EMBO J. 21 (24): 6915–24. doi:10.1093/emboj/cdf678. PMC 139098. PMID 12486012.
- Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.". RNA 8 (12): 1489–501. PMC 1370355. PMID 12515382.
- Grzymski EC (2003). "Visualizing an mRNA destruction line.". Nat. Struct. Biol. 10 (6): 416. doi:10.1038/nsb0603-416. PMID 12768200.
- Piccirillo C, Khanna R, Kiledjian M (2003). "Functional characterization of the mammalian mRNA decapping enzyme hDcp2.". RNA 9 (9): 1138–47. doi:10.1261/rna.5690503. PMC 1370477. PMID 12923261.
- Lejeune F, Li X, Maquat LE (2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities.". Mol. Cell 12 (3): 675–87. doi:10.1016/S1097-2765(03)00349-6. PMID 14527413.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Cougot N, Babajko S, Séraphin B (2004). "Cytoplasmic foci are sites of mRNA decay in human cells.". J. Cell Biol. 165 (1): 31–40. doi:10.1083/jcb.200309008. PMC 2172085. PMID 15067023.
- Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
- Liu SW, Jiao X, Liu H, et al. (2004). "Functional analysis of mRNA scavenger decapping enzymes.". RNA 10 (9): 1412–22. doi:10.1261/rna.7660804. PMC 1370627. PMID 15273322.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (2005). "MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies.". Nat. Cell Biol. 7 (7): 719–23. doi:10.1038/ncb1274. PMC 1855297. PMID 15937477.
- Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (2006). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping.". Mol. Cell 20 (6): 905–15. doi:10.1016/j.molcel.2005.10.031. PMID 16364915.
- Wichroski MJ, Robb GB, Rana TM (2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.". PLoS Pathog. 2 (5): e41. doi:10.1371/journal.ppat.0020041. PMC 1458959. PMID 16699599.
- Chu CY, Rana TM (2006). "Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.". PLoS Biol. 4 (7): e210. doi:10.1371/journal.pbio.0040210. PMC 1475773. PMID 16756390.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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