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THE LEGEND OF ZELDA RAP [MUSIC VIDEO]WATCH BLOOPERS & MORE: http://bit.ly/ZELDAxtras DOWNLOAD THE SONG: http://smo.sh/13NrBp8 DOWNLOAD UNCENSORED SONG: http://smo.sh/WMYpsf GET LEGEND OF SMOSH T...
David Guetta - Titanium ft. SiaFrom the album Nothing But The Beat Ultimate - Download on iTunes here: http://smarturl.it/NBTBiTunes?IQid=vevo Featuring Sia, Ne-Yo, Akon, Nicki Minaj, Flo ...
MACKLEMORE & RYAN LEWIS - THRIFT SHOP FEAT. WANZ (OFFICIAL VIDEO)Thrift Shop on iTunes: http://itunes.apple.com/us/album/thrift-shop-feat.-wanz-single/id556955707 The Heist physical deluxe edition: http://www.macklemoremer...
Rihanna - Rehab ft. Justin TimberlakeMusic video by Rihanna performing Rehab. YouTube view counts pre-VEVO: 19591123. (C) 2007 The Island Def Jam Music Group.
Man of Steel - Official Trailer 3 [HD]http://manofsteel.com http://www.facebook.com/manofsteel In theaters June 14th. From Warner Bros. and Legendary Pictures comes "Man of Steel", starring Henry...
P!nk - Just Give Me A Reason ft. Nate RuessFrom the Grammy Nominated album The Truth About Love available now - http://smarturl.it/tal Music video by P!nk featuring Nate Ruess performing Just Give Me ...
FIRETRUCK! (Official Music Video)BLOOPERS: http://bit.ly/FiretruckBloopers GET THE SONG: http://smo.sh/WMZv7l MILKSHAKE MUSIC VIDEO: http://bit.ly/MilkyMilkshake CHECK OUT THIS FIRETRUCK TEE...
Rihanna - Russian RouletteMusic video by Rihanna performing Russian Roulette. (C) 2009 The Island Def Jam Music Group.
PEWDIEPIE Song - Dj FortifyDue to so many request I decided to upload this epic track as well. Enjoy it bros!
One Direction - Little ThingsTAKE ME HOME The brand new album out now! Featuring Live While We're Young and Little Things. iTunes: http://smarturl.it/takemehome1D Amazon: http://amzn.to/...
Rihanna - Stay ft. Mikky EkkoDownload "Stay" from Unapologetic now: http://smarturl.it/UnapologeticDlx Music video by Rihanna performing Stay ft. Mikky Ekko. © 2013 The Island Def Jam Mu...
David Guetta - Just One Last Time ft. Taped Rai"Just One Last Time" feat. Taped Rai. Available to download on iTunes including remixes of : Tiësto, HARD ROCK SOFA & Deniz Koyu http://smarturl.it/DGJustOne...
MACKLEMORE & RYAN LEWIS - CAN'T HOLD US FEAT. RAY DALTON (OFFICIAL MUSIC VIDEO)Macklemore & Ryan Lewis present the official music video for Can't Hold Us feat. Ray Dalton. Can't Hold Us on iTunes: https://itunes.apple.com/us/album/cant-...
FUNNY GAMING MONTAGEI'm just a guy from Sweden who likes to laugh and make other people laugh. Sharing gaming moments on YouTube with my bros! Why not join us? :D Become a bro t...
Drive Thru Invisible Driver PrankLearn Magic at http://www.penguinmagic.com Instagram: http://instagram.com/themagicofrahat Twitter: http://twitter.com/magicofrahat Facebook Group: http://ww...
Draw My Life- Jenna MarblesThis video accidentally turned out kind of sad, ME SO SOWWY IT NOT POSED TO BE SAD WHO WANTS HUGS AND COOKIES? Also, FYI for anyone attempting this, it takes...
Rihanna - DiamondsPre-order new album Unapologetic, out worldwide Monday, November 19: http://smarturl.it/UnapologeticDlx Music video by Rihanna performing Diamonds. ©: The Is...
Rihanna - Pon de Replay (Internet Version)Music video by Rihanna performing Pon de Replay. YouTube view counts pre-VEVO: 4166822. (C) 2005 The Island Def Jam Music Group.
Rihanna - Only Girl (In The World)Music video by Rihanna performing Only Girl (In The World). (C) 2010 The Island Def Jam Music Group #VEVOCertified on February 16, 2011. http://www.vevo.com/...
Pokemon Theme Song REVENGE!BLOOPERS & DELETED SCENES: http://bit.ly/POKEMONbloopers DOWNLOAD THE SONG: http://smo.sh/WMZqR5 CHECK OUT THIS POKESMOSH SHIRT: http://smo.sh/YMRJ5e COLLECT...
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|---|---|
| Systematic (IUPAC) name | |
| 5-methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole | |
| Clinical data | |
| Pregnancy cat. | ? |
| Legal status | ? |
| Identifiers | |
| CAS number | 158942-04-2 |
| ATC code | ? |
| PubChem | CID 5163 |
| Chemical data | |
| Formula | C17H16N4O |
| Mol. mass | 292.334 g/mol |
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SB-206,553 is a drug which acts as a mixed antagonist for the 5-HT2B and 5-HT2C serotonin receptors.[1][2][3] It has anxiolytic properties in animal studies and interacts with a range of other drugs.[4][5][6][7][8][9][10][11][12] It has also been shown to act as a positive allosteric modulator of α7 nicotinic acetylcholine receptors.[13]
References [edit]
- ^ Forbes IT, Ham P, Booth DH, Martin RT, Thompson M, Baxter GS, Blackburn TP, Glen A, Kennett GA, Wood MD (July 1995). "5-Methyl-1-(3-pyridylcarbamoyl)-1,2,3,5-tetrahydropyrrolo[2,3-f]indole: a novel 5-HT2C/5-HT2B receptor antagonist with improved affinity, selectivity, and oral activity". Journal of Medicinal Chemistry 38 (14): 2524–30. doi:10.1021/jm00014a004. PMID 7629791.
- ^ Kennett GA, Wood MD, Bright F, Cilia J, Piper DC, Gager T, Thomas D, Baxter GS, Forbes IT, Ham P, Blackburn TP (February 1996). "In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties". British Journal of Pharmacology 117 (3): 427–434. PMC 1909304. PMID 8821530.
- ^ Forbes IT, Dabbs S, Duckworth DM, Ham P, Jones GE, King FD, Saunders DV, Blaney FE, Naylor CB, Baxter GS, Blackburn TP, Kennett GA, Wood MD (December 1996). "Synthesis, biological activity, and molecular modeling of selective 5-HT(2C/2B) receptor antagonists". Journal of Medicinal Chemistry 39 (25): 4966–77. doi:10.1021/jm960571v. PMID 8960557.
- ^ Bromidge SM, Dabbs S, Davies DT, Duckworth DM, Forbes IT, Ham P, Jones GE, King FD, Saunders DV, Starr S, Thewlis KM, Wyman PA, Blaney FE, Naylor CB, Bailey F, Blackburn TP, Holland V, Kennett GA, Riley GJ, Wood MD (May 1998). "Novel and selective 5-HT2C/2B receptor antagonists as potential anxiolytic agents: synthesis, quantitative structure-activity relationships, and molecular modeling of substituted 1-(3-pyridylcarbamoyl)indolines". Journal of Medicinal Chemistry 41 (10): 1598–612. doi:10.1021/jm970741j. PMID 9572885.
- ^ Di Matteo V, Di Giovanni G, Di Mascio M, Esposito E (1998). "Selective blockade of serotonin2C/2B receptors enhances dopamine release in the rat nucleus accumbens". Neuropharmacology 37 (2): 265–72. doi:10.1016/S0028-3908(98)00014-8. PMID 9680252.
- ^ McCreary AC, Cunningham KA (June 1999). "Effects of the 5-HT2C/2B antagonist SB 206553 on hyperactivity induced by cocaine". Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 20 (6): 556–64. doi:10.1016/S0893-133X(98)00087-6. PMID 10327425.
- ^ Di Giovanni G, De Deurwaerdére P, Di Mascio M, Di Matteo V, Esposito E, Spampinato U (1999). "Selective blockade of serotonin-2C/2B receptors enhances mesolimbic and mesostriatal dopaminergic function: a combined in vivo electrophysiological and microdialysis study". Neuroscience 91 (2): 587–97. doi:10.1016/S0306-4522(98)00655-1. PMID 10366016.
- ^ Takahashi RN, Berton O, Mormède P, Chaouloff F (May 2001). "Strain-dependent effects of diazepam and the 5-HT2B/2C receptor antagonist SB 206553 in spontaneously hypertensive and Lewis rats tested in the elevated plus-maze". Brazilian Journal of Medical and Biological Research 34 (5): 675–82. PMID 11323756.
- ^ Porras G, Di Matteo V, Fracasso C, Lucas G, De Deurwaerdère P, Caccia S, Esposito E, Spampinato U (March 2002). "5-HT2A and 5-HT2C/2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum". Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 26 (3): 311–24. doi:10.1016/S0893-133X(01)00333-5. PMID 11850146.
- ^ Navailles S, De Deurwaerdère P, Porras G, Spampinato U (February 2004). "In vivo evidence that 5-HT2C receptor antagonist but not agonist modulates cocaine-induced dopamine outflow in the rat nucleus accumbens and striatum". Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 29 (2): 319–26. doi:10.1038/sj.npp.1300329. PMID 14560323.
- ^ Canal CE, Olaghere da Silva UB, Gresch PJ, Watt EE, Sanders-Bush E, Airey DC (April 2010). "The serotonin 2C receptor potently modulates the head-twitch response in mice induced by a phenethylamine hallucinogen". Psychopharmacology 209 (2): 163–74. doi:10.1007/s00213-010-1784-0. PMC 2868321. PMID 20165943.
- ^ Graves, S. M.; Napier, T. C. (2012). "SB 206553, a putative 5-HT2C inverse agonist, attenuates methamphetamine-seeking in rats". BMC Neuroscience 13: 65. doi:10.1186/1471-2202-13-65. PMID 22697313.
- ^ Dunlop J, Lock T, Jow B, Sitzia F, Grauer S, Jow F, Kramer A, Bowlby MR, Randall A, Kowal D, Gilbert A, Comery TA, Larocque J, Soloveva V, Brown J, Roncarati R (March 2009). "Old and new pharmacology: positive allosteric modulation of the alpha7 nicotinic acetylcholine receptor by the 5-hydroxytryptamine(2B/C) receptor antagonist SB-206553 (3,5-dihydro-5-methyl-N-3-pyridinylbenzo[1,2-b:4,5-b']di pyrrole-1(2H)-carboxamide)". The Journal of Pharmacology and Experimental Therapeutics 328 (3): 766–76. doi:10.1124/jpet.108.146514. PMID 19050173.
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